Browse our Isle of Palms rentals. Isle of Palms is a barrier island about 15 miles from downtown Charleston known for its pristine beaches, championship golf courses, parks, marina, and more. Situated between the Intracoastal Waterway and the Atlantic Ocean, Isle of Palms has long been a popular vacation spot along the South Carolina Coast. Experience the seclusion of the islands of Charleston while still being a short drive from the city’s historic attractions, world-class dining, and more. Book home or condo rentals on Isle of Palms that can fit groups of all sizes.